United States securities and exchange commission logo

                             September 27, 2023

       Morgan Brown
       Chief Financial Officer
       Clene Inc.
       6550 South Millrock Drive, Suite G50
       Salt Lake City, UT 84121

                                                        Re: Clene Inc.
Statement on Form S-3
                                                            Filed September 22,
                                                            File No. 333-274651

       Dear Morgan Brown:

              We have limited our review of your registration statement to
those issues we have
       addressed in our comment. In our comment we may ask you to provide us
with information so
       we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form S-3 filed September 22, 2023


   1.                                                   In relation to the
3,000,000 shares of common stock underlying a warrant issued as part of
                                                        an amendment to a loan
and security agreement between you and Avenue Venture
                                                        Opportunities Fund,
L.P. (the "Warrant"), please tell us your basis for registering the
                                                        offering of these
shares on a primary basis. In this regard, we note that the Warrant was
                                                        issued pursuant to
Section 4(a)(2) of the Securities Act and Rule 506(b) of Regulation D
                                                        promulgated thereunder
and is exercisable within one year. Please consider the rationale
                                                        set out in Securities
Act Sections C&DI Questions 139.08, 239.15, and 103.04.

              We remind you that the company and its management are responsible
for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
 Morgan Brown
Clene Inc.
September 27, 2023
Page 2

action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration

       You may contact Lauren Hamill at 303-844-1008 or Laura Crotty at
202-551-7614 with
any questions.

FirstName LastNameMorgan Brown
                                                           Division of
Corporation Finance
Comapany NameClene Inc.
                                                           Office of Life
September 27, 2023 Page 2
cc:       Tom McAleavey
FirstName LastName